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DIOXOPROMETHAZINE HCl

DIOXOPROMETHAZINE HCl

CAS: 13754-56-8

Molecular Formula: C17H20N2O2S

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DIOXOPROMETHAZINE HCl - Names and Identifiers

Name DIOXOPROMETHAZINE HCl
Synonyms Prothanon
Dioxoprome
Dioxypromethazine
DIOXOPROMETHAZINE HCl
DIOXOPROMETHAZINE HCL
9,9-Dioxopromethazine
Dioxopromethaxine Hydrochloride
10-[2-(Dimethylamino)propyl]-10H-phenothiazine 5,5-dioxide
N,N,α-Trimethyl-10H-phenothiazine-10-ethanamine 5,5-dioxide
1-(5,5-Dioxido-10H-phenothiazin-10-yl)-N,N-dimethylpropan-2-amine
10H-phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5,5-dioxide
10H-Phenothiazine-10-ethanamine, N,N,alpha-trimethyl-, 5,5-dioxide (9CI)
CAS 13754-56-8
EINECS 1308068-626-2
InChI InChI=1/C17H20N2O2S/c1-13(18(2)3)12-19-14-8-4-6-10-16(14)22(20,21)17-11-7-5-9-15(17)19/h4-11,13H,12H2,1-3H3

DIOXOPROMETHAZINE HCl - Physico-chemical Properties

Molecular FormulaC17H20N2O2S
Molar Mass316.42
Density1.224
Melting Point127-129℃
Boling Point478.5±34.0 °C(Predicted)
Flash Point243.2°C
Solubility Chloroform (Slightly), Methanol (Slightly, Heated)
Vapor Presure2.57E-09mmHg at 25°C
AppearanceSolid
ColorLight Beige
pKa8.88±0.50(Predicted)
Storage ConditionRefrigerator
Refractive Index1.605
Physical and Chemical PropertiesWhite or yellowish powder or crystalline powder, odorless, bitter taste. Soluble in water, slightly soluble in ethanol.

DIOXOPROMETHAZINE HCl - Standard

Authoritative Data Verified Data

This product is the hydrochloride salt of 10-(2-dimethylamino-propyl) phenothiazine-5, 5-dioxide. The content of C17H20N202S • HC1 shall not be less than 99.0% based on dry products.

Last Update：2024-01-02 23:10:35

DIOXOPROMETHAZINE HCl - Trait

Authoritative Data Verified Data
  • This product is internal color to yellowish powder or crystalline powder; Odorless.
  • This product is dissolved in water, and it is very slightly dissolved in ethanol.

absorption coefficient

take this product, precision weighing, add 0.1 mol/L hydrochloric acid solution was dissolved and quantitatively diluted to prepare a solution containing 10ug per 1 ml, and the absorbance was measured at the wavelength of 264nm by UV-visible spectrophotometry (General rule 0401), the absorption coefficient is 350 to 370.

Last Update：2022-01-01 14:19:56

DIOXOPROMETHAZINE HCl - Differential diagnosis

Authoritative Data Verified Data
  1. the solution under the term of absorption coefficient was taken and measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of 290 nm, nm, nm and 328nm. The absorbance at a wavelength of 328NM was 0.15 to 0.18.
  2. The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 322).
  3. the product of the aqueous solution of the chloride identification (1) of the reaction (General 0301).
Last Update：2022-01-01 14:19:57

DIOXOPROMETHAZINE HCl - Exam

Authoritative Data Verified Data

acidity

take 0.5g of this product, add 25ml of water to dissolve, and measure according to law (General rule 0631). The pH value should be 4.2~5.1.

clarity and color of solution

take 0.2g of this product, add water 10ml to dissolve, the solution should be clear and colorless; If the color is colored, compared with the yellow 2 Standard Colorimetric solution (General rule 0901 first method), not deeper.

sulfate

take 1.2g of this product and check it according to law (General rule 0802). Compared with the control solution made of 3ml of standard potassium sulfate solution, it should not be more concentrated (0.025%).

Related substances

take an appropriate amount of this product, add the mobile phase to dissolve and dilute to make a solution containing 0.3mg per lml as a test solution; Take an appropriate amount for precision measurement, A solution containing 3 WDS per 1ml was prepared as a control solution by quantitative dilution with the mobile phase. According to the test of high performance liquid chromatography (General rule 0512), silica gel was bonded with eighteen alkyl silane as the filler; 0.05 mL of acetate buffer solution (mol/L ammonium acetate solution) was added with 1ml of triethylamine, the pH was adjusted to 6.5 with acetic acid)-acetonitrile (75:25) as the mobile phase; The detection wavelength was 258mn. The number of theoretical plates is not less than 5000 based on the dioxopromethazine peak. 20 u1 of the test solution and the control solution were respectively injected into the human liquid chromatograph, and the chromatogram was recorded to 2 times of the retention time of the main component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than 0.5 times (0.5%) the area of the main peak of the control solution, and the sum of the areas of each impurity peak shall not be greater than the area of the main peak of the control solution (1.0%).

loss on drying

take this product, dry to constant weight at 105°C, weight loss shall not exceed 0.5% (General rule 0831).

ignition residue

take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.

Heavy metals

The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).

Last Update：2022-01-01 14:19:58

DIOXOPROMETHAZINE HCl - Content determination

Authoritative Data Verified Data

take about 0.3g of this product, precision weighing, add 25ml of glacial acetic acid and 10ml of Mercury acetate test solution, dissolve at a slight temperature, cool, add 1~2 drops of crystal violet indicator solution, with perchloric acid titration solution (0.1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 35.29mg of c17h20n2o2s-hc1.

Last Update：2022-01-01 14:19:58

DIOXOPROMETHAZINE HCl - Category

Authoritative Data Verified Data

antitussive drugs.

Last Update：2022-01-01 14:19:58

DIOXOPROMETHAZINE HCl - Storage

Authoritative Data Verified Data

light shielding, sealed storage.

Last Update：2022-01-01 14:19:58

DIOXOPROMETHAZINE HCl - Dioxopromethazine Hydrochloride Tablets

Authoritative Data Verified Data

This product contains dioxopromethazine hydrochloride (C17H20N202S • HC1) should be 90.0% ~ 110.0% of the label amount.

trait

This product is a white tablet or sugar-coated tablet, White after removing the coating.

identification

  1. the solution under the content measurement item was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at wavelengths of NM, NM, 290nm and 328nm.
  2. This product water solution chloride identification (1) of the reaction (General 0301).

examination

  • Content uniformity take 1 tablet of this product, grind, add 0.40ml of 1 mol/L hydrochloric acid solution was added, and the solution was divided into a 50ml measuring flask, and shaken for 15 minutes to dissolve dioxopromethazine hydrochloride. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in 50ml measuring flask, use 0. Dilute lmol/L hydrochloric acid solution to the scale, shake well, measure absorbance at 0401 wavelength according to UV-Vis spectrophotometry (General 2641101), the content calculated with the absorption coefficient of C17H20N202S • HC1 of 362 shall be in accordance with the regulations (General 0941).
  • others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).

Content determination

take 12 tablets of this product, put it in a 200ml measuring flask, add 0.1 mol/L hydrochloric acid solution about 150ml, shake to dissolve dioxopromethazine hydrochloride, with 0. Dilute 1 mol/L hydrochloric acid solution to the scale, shake well, filter, Take 5ml of continuous filtrate accurately, put it in a 100ml measuring flask, use 0.1 mol/L hydrochloric acid solution diluted to the scale, shake, according to UV-visible spectrophotometry (General 0401), at the wavelength of 264nm absorbance, the absorption coefficient of C17H20N202S. HC1 was calculated as 362.

category

with dioxopromethazine hydrochloride.

specification

5mg

storage

light shielding, sealed storage.

Last Update：2022-01-01 14:19:59
DIOXOPROMETHAZINE HCl
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CAS: 13754-56-8
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MedChemExpress (MCE)
Spot supply
Product Name: Prothanon; 9,9-Dioxopromethazine; 9,9-Dioxypromethazin Visit Supplier Webpage Request for quotation
CAS: 13754-56-8
Tel: 609-228-6898
Email: sales@medchemexpress.com
　　　　 tech@medchemexpress.com
Mobile: 609-228-6898
SKYRUN INDUSTRIAL CO.,LTD
Spot supply
Product Name: DIOXOPROMETHAZINE HCL Visit Supplier Webpage Request for quotation
CAS: 13754-56-8
Tel: +86 0571-86722205
Email: sales@chinaskyrun.com
Mobile: +8618958170122
QQ: 2531159185 Click to send a QQ messageSend QQ message
Wechat: chinaskyrun
Hefei TNJ Chemical Industry Co.,Ltd.
Product Name: DIOXOPROMETHAZINE HCl Request for quotation
CAS: 13754-56-8
Tel: 0086-551-65418684
Email: sales@tnjchem.com
　　　　 info@tnjchem.com
Mobile: 0086 189 4982 3763
QQ: 2881500840 Click to send a QQ message
Wechat: 189 4982 3763
WhatsApp: 0086 189 4982 3763
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View History
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